A major area of research in our lab focuses on the use of oncolytic viruses as cancer therapeutics. We are particularly interested in understanding the interplay between tumor cell metabolism, virus replication, and antiviral immunity. Our research aims to identify metabolic pathways in tumor cells that regulate oncolytic virus replication and to manipulate tumor cell metabolism to improve oncolytic virus therapy.

Because the induction of potent anti-tumor immune responses is an important mechanism by which oncolytic viruses work, another goal of our research is to understand the impact of metabolism on the function of T cells in the context of cancer immunotherapy.