Microfluidics

List of publications on which the expertise of the microfluidics core facility is based and in which members of the core facility have participated.

Microdissected tissues 

M. Astolfi, B. Péant, M. A. Lateef, N. Rousset, J. Kendall-Dupont, E. Carmona, F. Monet, F. Saad, D. Provencher, A.-M. Mes-Masson et T. Gervais, “Micro-dissected tumor tissues on chip: an ex vivo method for drug testing and personalized therapy,” Lab Chip, 16, 312-325, 2016, DOI: https://doi.org/10.1039/C5LC01108F.

R. Guay Lord, M.A. Lateef, K. Simeone, B. Péant, J. Kendall-Dupont, A.-M. Mes-Masson, T. Gervais, F. Saad (2017). Microfluidic Devices and Micro-Dissected Tissue to Predict Therapeutic Response in patients with Prostate Cancer. Ed H. Chen, Advances in Experimental Surgery. New York, USA: Nova Science Publisher Inc. ISBN: 978-1-53612-773-7.

Simulation of the viability of 3D culture models

N. Rousset, F. Monet et T. Gervais, “Simulation-assisted design of microfluidic sample traps for optimal trapping and culture of non-adherent single cells, tissues, and spheroids,” Scientific Reports, 7, 245, 2017, DOI: https://doi.org/10.1038/s41598-017-00229-1.

Formation, culture and analysis of spheroids

M. Marimuthu, N. Rousset, A. St-Georges-Robillard, M. A. Lateef, M. Ferland, A.-M. Mes-Masson and T.vGervais (2018). Multi-size spheroid formation using microfluidic funnels. Lab Chip. 2018 Jan 16;18(2):304-314. DOI: https://doi.org/10.1039/c7lc00970d.

A. St-Georges-Robillard, M. Masse, M. Cahuzac, M. Strupler, B. Patra, A.M. Orimoto, J. Kendall-Dupont, B. Péant, A.-M. Mes-Masson, F. Leblond and T. Gervais (2018). Fluorescence hyperspectral imaging for live monitoring of multiple spheroids in microfluidic chips. Analyst. 2018 Aug 6;143(16):3829-3840. DOI: https://doi.org/10.1039/c8an00536b.

A. St-Georges-Robillard, M. Cahuzac, B. Péant, H. Fleury, M. A. Lateef, A. Ricard, A. Sauriol, F. Leblond, A.-M. Mes-Masson and T. Gervais (2019). Long-term fluorescence hyperspectral imaging of on-chip treated co-culture tumour spheroids to follow clonal evolution. Integr Biol (Camb). 2019 Apr 1;11(4):130-141. DOI: https://doi.org/10.1093/intbio/zyz012.

B. Patra, M. A. Lateef, M. N. Brodeur, H. Fleury, E. Carmona, B. Péant, D. Provencher, A.-M. Mes-Masson and T. Gervais (2020). Carboplatin sensitivity in epithelial ovarian cancer cell lines: The impact of model systems. PLoS One. 2020 Dec 31;15(12):e0244549. DOI: https://doi.org/10.1371/journal.pone.0244549

Paraffin-embedding of microdissected tissues

K. Simeone, R. Guay-Lord, M. A. Lateef, B. Péant, J. Kendall-Dupont, A. M. Orimoto, E. Carmona, D. Provencher, F. Saad, T. Gervais et A.-M. Mes-Masson, “Paraffin-embedding lithography and micro-dissected tissue micro-arrays: tools for biological and pharmacological analysis of ex vivo solid tumors,” Lab Chip, 19, 693-705, 2019, DOI: https://doi.org/10.1039/C8LC00982A.

List of publications in which the authors thank the CRCHUM microfluidics core facility for its help.

M. N. Brodeur, K. Simeone, K. Leclerc-Deslauniers, H. Fleury, E. Carmona, D. M. Provencher and A.-M. Mes-Masson (2021). Carboplatin response in preclinical models for ovarian cancer: comparison of 2D monolayers, spheroids, ex vivo tumors and in vivo models. Sci Rep. 2021 Sep 14;11(1):18183. DOI: https://doi.org/10.1038/s41598-021-97434-w

D. Dorrigiv, K. Simeone, L. Communal, J. Kendall-Dupont, A. St-Georges-Robillard, B. Péant, E. Carmona, A.-M. Mes-Masson et T. Gervais (2021). Microdissected Tissue vs Tissue Slices—A Comparative Study of Tumor Explant Models Cultured On-Chip and Off-Chip. Cancers, 13(16), 4208, 2021, DOI: https://doi.org/10.3390/cancers13164208.

D. Dorrigiv, P.-A. Goyette, A. St-Georges-Robillard, A.-M. Mes-Masson and T. Gervais (2023). Pixelated Microfluidics for Drug Screening on Tumour Spheroids and Ex Vivo Microdissected Tumour Explants. Cancers (Basel). 2023 Feb 7;15(4):1060. DOI: https://doi.org/10.3390/cancers15041060.