Molecular pathology

The Molecular Pathology Core Facility has contributed to the publication of the following scientific articles.

^{Karen Geoffroy, Patrick Laplante, Sylvie Clairefond, Feryel Azzi, Dominique Trudel , Jean-Baptiste Lattouf , John Stagg, Fred Saad, Anne-Marie Mes-Masson, Marie-Claude Bourgeois-Daigneault and Jean-François Cailhier. High Levels of MFG-E8 Confer a Good Prognosis in Prostate and Renal Cancer Patients. Cancers 2022, 14(11), 2790; https://doi.org/10.3390/cancers14112790}

^{Charles Dariane, Sylvie Clairefond, Benjamin Péant, Laudine Communal, Zhe Thian, Véronique Ouellet, Dominique Trudel, Nazim Benzerdjeb, Feryel Azzi, Arnaud Méjean, Marc-Olivier Timsit, Manon Baurès, Jacques-Emmanuel Guidotti, Vincent Goffin, Pierre I Karakiewicz, Anne-Marie Mes-Masson, Fred Saad. High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortalit. Cancers (Basel). 2022. Mar 23;14(7):1623. doi: 10.3390/cancers14071623.}

^{Ouellet V, Erickson A; GAP1 UTMAs Contributing Investigators; Wiley K, Morrissey C, Berge V, Moreno CS, Tasken KA, Trudel D, True LD, Lewis MS, Svindland  A, Ertunc O, Vidal ID, Osunkoya AO, Jones T, Bova GS, Lamminen T, Achtman AH, Buzza M, Kouspou MM, Bigler  SA, Zhou X, Freedland SJ, Mes-Masson AM, Garraway IP, Trock BJ, Taimen P, Saad F, Mirtti T, Knudsen BS, De Marzo AM. The Movember Global Action Plan 1 (GAP1): Unique Prostate Cancer Tissue Microarray Resource. Cancer Epidemiol Biomarkers Prev. 2022 Apr 1;31(4):715-727. doi: 10.1158/1055-9965.EPI-21-0600.}

^{Bareche Y, Pommey S, Carneiro M, Buisseret L, Cousineau I, Thebault P, Chrobak P, Communal L, Allard D, Robson SC, Mes-Masson AM, Provencher D, Lapointe R, Stagg J. High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer. Meta-Analysis J Immunother Cancer. 2021 Mar;9(3):e001965. doi: 10.1136/jitc-2020-001965.}

^{Clairefond S, Ouellet V, Péant B, Barrès V, Karakiewicz PI, Mes-Masson AM, Saad F. Expression of ERBB Family Members as Predictive Markers of Prostate Cancer Progression and Mortality. Cancers (Basel). 2021 Apr 2;13(7):1688. doi: 10.3390/cancers13071688.}

^{Communal L, Roy N, Cahuzac M, Rahimi K, Köbel M, Provencher DM, Mes-Masson AM. A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis. Int J Mol Sci. 2021 May 18;22(10):5325. doi: 10.3390/ijms22105325.}

^{Clairefond S, Péant B, Ouellet V, Barrès V, Tian Z, Trudel D, Karakiewicz PI, Mes-Masson AM, Saad F. PUMA and NOXA Expression in Tumor-Associated Benign Prostatic Epithelial Cells Are Predictive of Prostate Cancer Biochemical Recurrence. Cancers (Basel). 2020 Oct 29;12(11):3187. doi: 10.3390/cancers12113187.}

^{Manuel Flores Molina, Thomas Fabre, Aurélie Cleret-Buhot, Geneviève Soucy, Liliane Meunier, Mohamed N. Abdelnabi, Nicolas Belforte, Simon Turcotte, Naglaa H. Shoukry. Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment. JoVE 2020. DOI:10.3791/60740}

^{Caitlin T Fierheller, Laure Guitton-Sert, Wejdan M Alenezi, Timothée Revil,Kathleen, Oros, Karine Bedard, Suzanna Arcand, Corinne Serruya, Supriya Behl, Liliane Meunier, Hubert Fleury,Eleanor Fewings, Deepak N Subramanian, Javad Nadaf, Diane Provencher, William D Foulkes, Zaki El Haffaf,Anne-Marie Mes-Masson, Jacek Majewski, Marc Tischkowitz, Paul A James, Ian G Campbell, Celia M T Greenwood,Jiannis Ragoussis, Jean-Yves Masson, Patricia N Tonin. The genetic analysis of a founder Northern American population of European descent identifies FANCI as a candidate familial ovarian cancer risk gene. medRxiv. doi: https://doi.org/10.1101/2020.05.04.20090407}

^{Le Page C, Rahimi K, Rodrigues M, Heinzelmann-Schwarz V, Recio N, Tommasi S, Bataillon G, Portelance L, Golmard L, Meunier L, Tonin PN, Gotlieb W, Yasmeen A, Ray-Coquard I, Labidi-Galy SI, Provencher D, Mes-Masson AM. Clinicopathological features of women with epithelial ovarian cancer and double heterozygosity for BRCA1 and BRCA2: A systematic review and case report analysis. Gynecol Oncol. 2019 Nov 18. pii: S0090-8258(19)31670-1. doi: 10.1016/j.ygyno.2019.11.019.}

^{Le Page C, Chung J, Rahimi K, Kobel M, Provencher D, Mes-Masson AM. Exploring the Clinical Impact of Predictive Biomarkers in Serous Ovarian Carcinomas. Curr Drug Targets. 2019 Oct 16. doi: 10.2174/1389450120666191016143836. [Epub ahead of print] PMID: 31622218}

^{Le Page C, Köbel M, Meunier L, Provencher DM, Mes-Masson AM, Rahimi K. A COEUR cohort study of SATB2 expression and its prognostic value in ovarian endometrioid carcinoma. J Pathol Clin Res. 2019 Jul;5(3):177-188. doi: 10.1002/cjp2.131. Epub 2019 Apr 20. PMID: 30924313. Free PMC Article}

^{Grosset AA1,2, Ouellet V1,2, Caron C1,2, Fragoso G1,2, Barrès V1,2, Delvoye N1,2, Latour M1, Aprikian A3, Bergeron A4,5,6, Chevalier S3, Fazli L7, Fleshner N8, Gleave M7, Karakiewicz P1,2, Lacombe L4,5,6, Lattouf JB1,2, van der Kwast T8, Trudel D1,2, Mes-Masson AM1,2, Saad F1,2; Canadian Prostate Cancer Biomarker Network. Validation of the prognostic value of NF-κB p65 in prostate cancer: A retrospective study using a large multi-institutional cohort of the Canadian Prostate Cancer Biomarker Network. PLoS Med. 2019 Jul 2;16(7):e1002847. doi: 10.1371/journal.pmed.1002847. eCollection 2019 Jul. PMID: 31265453}

^{Dankner M1, Ouellet V2, Communal L2, Schmitt E2, Perkins D1, Annis MG1, Barrès V2, Caron C2, Mes-Masson  AM3, Saad F4, Siegel PM5; Canadian Prostate Cancer Biomarker Network. CCN3/Nephroblastoma Overexpressed Is a Functional Mediator of Prostate Cancer Bone Metastasis That Is Associated with Poor Patient Prognosis. Am J Pathol. 2019 Jul;189(7):1451-1461. doi: 10.1016/j.ajpath.2019.04.006. Epub 2019 Jun 12. PMID: 31202437}

^{Dhaeze T1, Tremblay L1, Lachance C1, Peelen E1, Zandee S1, Grasmuck C1, Bourbonnière L1, Larouche S1, Ayrignac X1,2, Rébillard RM1, Poirier J2, Lahav B2, Duquette P1,2, Girard M1,2, Moumdjian R3, Bouthillier A3, Larochelle C1,2, Prat A4,5. CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis. Cell Mol Immunol. 2019 Jul;16(7):652-665. doi: 10.1038/s41423-018-0198-5. Epub 2019 Jan 11. PMID: 30635649}

^{Fleury H1,2, Malaquin N1,2, Tu V1,2, Gilbert S1,2, Martinez A1,2, Olivier MA1,2, Sauriol A1,2, Communal L1,2, Leclerc-Desaulniers K1,2, Carmona E1,2, Provencher D1,2,3, Mes-Masson AM4,5,6, Rodier F7,8,9. Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence. Nat Commun. 2019 Jun 11;10(1):2556. doi: 10.1038/s41467-019-10460-1. PMID: 31186408}

^{Cécile Le Page, 1 Martin Köbel, 2 Liliane Meunier, 1 Diane M Provencher, 1 , 3 Anne‐Marie Mes‐Masson, 1 , 4 and Kurosh Rahimicorresponding author 1 , 5 A COEUR cohort study of SATB2 expression and its prognostic value in ovarian endometrioid carcinoma. J Pathol Clin Res. 2019 Jul;5(3):177-188. doi: 10.1002/cjp2.131. Epub 2019 Apr 20. PMID: 30924313}

^{Monette A1,2,3, Bergeron D4, Ben Amor A5, Meunier L6,7, Caron C6,7, Mes-Masson AM6,7,4, Kchir N8, Hamzaoui K5,9, Jurisica I10,11, Lapointe R12,13,14. Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification. J Immunother Cancer. 2019 Mar 28;7(1):86. doi: 10.1186/s40425-019-0544-x. PMID: 30922393.}

^{Gaudreau PO1, Clairefond S2, Class CA3, Boulay PL4, Chrobak P2, Allard B2, Azzi F5, Pommey S2, Do KA3, Saad F6, Trudel D7, Young M8, Stagg J9. WISP1 is associated to advanced disease, EMT and an inflamed tumor microenvironment in multiple solid tumors. Oncoimmunology. 2019 Mar 22;8(5):e1581545. doi: 10.1080/2162402X.2019.1581545. eCollection 2019. PMID: 31069142}

^{Kayla Simeone, ‡ab Robin Guay-Lord, ‡ac Mohammad Abdul Lateef,ab Benjamin Péant,a Jennifer Kendall Dupont,a Adriana Mari Orimoto,a Euridice Carmona,a Diane Provencher,ab Fred Saad, ab Thomas Gervais *ac and Anne-Marie Mes-Masson *ab. Paraffin-embedding lithography and microdissected tissue micro-arrays: tools for biological and pharmacological analysis of ex vivo solid tumors†. Lab Chip. 2019 Feb 12;19(4):693-705. doi: 10.1039/c8lc00982a. PMID: 30671574}

^{Thomas Fabre1,2,*, Manuel Flores Molina1,2, Geneviève Soucy1,3, Jean-Philippe Goulet4, Bernard Willems1,5, Jean-Pierre Villeneuve1,5, Marc Bilodeau1,5 and Naglaa H. Shoukry1,5,† Type 3 cytokines IL-17A and IL-22 drive TGF-β–dependent liver fibrosis. Sci Immunol. 2018 Oct 26;3(28). PMID: 30366940 DOI: 10.1126/sciimmunol.aar7754}

^{Ouellet V1, Aprikian A2, Bergeron A3, Brimo F4, Bristow RG5,6, Chevalier S2, Drachenberg D7, Fazli L8, Fleshner NE6,9, Gleave M8,10, Karakiewicz P11,12, Klotz L13, Lacombe L3, Lattouf JB1,12, van der Kwast T6, Squire JA14,15, Latour M1,16, Trudel D1,16, Mes-Masson AM1,17, Saad F18,19. The Terry Fox Research Institute Canadian Prostate Cancer Biomarker Network: an analysis of a pan-Canadian multi-center cohort for biomarker validation. BMC Urol. 2018 Sep 10;18(1):78. doi: 10.1186/s12894-018-0392-x. PMID: 30200929}

^{Yang B1,2,3, Lan S1,2,3, Dieudé M1,2,3, Sabo-Vatasescu JP1, Karakeussian-Rimbaud A1,2, Turgeon J1,2, Qi S1,2, Gunaratnam L2,4, Patey N5,2,3,6, Hébert MJ5,2,3. Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2018 Jul;29(7):1900-1916. doi: 10.1681/ASN.2017050581. Epub 2018 Jun 20. PMID: 29925521}

^{Khalfallah Y1,2, Kuta R3, Grasmuck C4,2, Prat A4,2, Durham HD3, Vande Velde C5,6,7. TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types. Sci Rep. 2018 May 15;8(1):7551. doi: 10.1038/s41598-018-25767-0. PMID: 29765078}

^{Mehta H1, Goulet PO1, Mashiko S1, Desjardins J1, Pérez G2, Koenig M2, Senécal JL2, Constante M3, Santos MM3, Sarfati M4 Early-Life Antibiotic Exposure Causes Intestinal Dysbiosis and Exacerbates Skin and Lung Pathology in Experimental Systemic Sclerosis. J Invest Dermatol. 2017 Nov;137(11):2316-2325. doi: 10.1016/j.jid.2017.06.019. Epub 2017 Jul 27. PMID: 28757138}

^{Berania I1,2, Cardin GB1, Clément I1, Guertin L2, Ayad  T2, Bissada E2, Nguyen-Tan PF3, Filion E3, Guilmette J4,5, Gologan O4, Soulieres D6, Rodier F1,7,Wong P1,3, Christopoulos A1,2. Four PTEN-targeting co-expressed miRNAs and ACTN4- targeting miR-548b are independent prognostic biomarkers in human squamous cell carcinoma of the oral tongue. Int J Cancer. 2017 Dec 1;141(11):2318-2328. doi: 10.1002/ijc.30915. Epub 2017 Aug 18. PMID: 28779483}

^{Mehta H1, Goulet PO1, Nguyen V1, Pérez G2, Koenig M2, Senécal JL2, Sarfati M1. Topoisomerase I peptide-loaded dendritic cells induce autoantibody response as well as skin and lung fibrosis. Autoimmunity. 2016 Dec;49(8):503-513. Epub 2016 Nov 3. PMID: 27808577}

^{Brissette MJ1,2, Laplante P1,2, Qi S1, Latour M3, Cailhier JF4,2,5. Milk fat globule epidermal growth factor-8 limits tissue damage through inflammasome modulation during renal injury. J Leukoc Biol. 2016 Nov;100(5):1135-1146. Epub 2016  Jun 3. PMID: 27260955}

^{Fournier P1, Dussault S2, Fusco A3, Rivard A4, Royal I5. Tyrosine Phosphatase PTPRJ/DEP-1 Is an Essential Promoter of Vascular Permeability, Angiogenesis, and Tumor Progression. Cancer Res. 2016 Sep 1;76(17):5080-91. doi: 10.1158/0008-5472.CAN-16-1071. Epub 2016 Jun 30. PMID: 27364551}