Métabolomique

La plateforme de métabolomique du CRCHUM a contribué à la publication de près d’une trentaine d’articles scientifiques depuis 2013.

Contributions de la plateforme de métabolomique

29. ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice. Lau D, Tobin S, Pribiag H, Nakajima1 S, Fisette A, Matthys D, Franco Flores AK, Peyot ML, Madiraju SRM, Prentki M, Stellwagen D, Alquier T, Fulton S. Nature Communications. 2024. 15:10652

28. Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice. Oppong A, Leung YH, Ghosh A, Peyot ML, Paquet M, Morales C, Clarke HJ, Al-Mulla F, Boyer A, Madiraju SRM, Boerboom D, O'Flaherty C, Prentki, M. Molecular Metabolism. 2024. 102063

27. Modulating Gut Microbiota Prevents Anastomotic Leak to Reduce Local Implantation and Dissemination of Colorectal Cancer Cells after Surgery. Hajjar R, Oliero M, Fragoso G, Ajayi AS, Alaoui AA, Rendos HV, Calve A, Cuisiniere T, Gerkins C, Therien S, Taleb N, Dagbert F, Sebajang H, Loungnarath R, Schwenter F, Ratelle R, Wassef R, De Broux E, Richard C, Santos MM. Clinical Cancer Research. 2024. 30(3): 616-628

26. Impact of the delay in cryopreservation timing during biobanking procedures on human liver tissue metabolomics. Goossens C, Tambay V, Raymond VA, Rousseau L, Turcotte S, Bilodeau M. PLoS One. 2024. 19(6):e0304405

25. Putrescine Supplementation Limits the Expansion of pks+ Escherichia coli and Tumor Development in the Colon. Oliero M, Cuisiniere T, Ajayi AS, Gerkins C, Hajjar R, Fragoso G, Calve A, Vennin Rendos H, Mathieu-Denoncourt A, Dagbert F, De Broux E, Loungnarath R, Schwenter F, Sebajang H, Ratelle R, Wassef R, Richard C, Duperthuy M, Gravel AE, Vincent AT, Santos MM. Cancer Res Commun. 2024. 4(7):1777-1792

24. Inulin impacts tumorigenesis promotion by colibactin-producing Escherichia coli in ApcMin/+ mice. Oliero M, Hajjar R, Cuisiniere T, Fragoso G, Calvé A, Santos MM. Front Microbiol. 2023. 14:1067505

23. Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans. Possik E, Klein LL, Sanjab P, Zhu R, Côté L, Bai Y, Zhang D, Sun H, Al-Mass A, Oppong A, Ahmad R, Parker A, Madiraju SRM, Al-Mulla F, Prentki, M. Nature Communications. 2023. 14:5214

22. Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia. Al-Mass A, Poursharifi P, Peyot ML, Lussier R, Chenier I, Leung YH, Ghosh A, Oppong A, Possik E, Mugabo Y, Ahmad R, Sladek R, Madiraju SRM, Al-Mulla F, Prentki M. Mol Metab. 2022. 66:101609

21. Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress. Al-Mass A, Poursharifi P, Peyot ML, Lussier R, Levens EJ, Guida J, Mugabo Y, Possik E, Ahmad R, Al-Mulla F, Sladek R, Madiraju SRM, Prentki M. Mol Metab. 2022. 60:101471

20. Very long-chain unsaturated sphingolipids mediate oleate-induced rat β-cell proliferation. Castell A-L, Vivoli A, Tippetts TS, Robillard Frayne I, Angeles ZE, Moullé VS, Campbell SA, Ruiz M, Ghislain J, Des Rosiers C, Holland WL, Summers SA, Poitout V. Diabetes. Publié en ligne le 14 mars 2022

19. Valuable alkaloids content is preserved in Camptotheca acuminata and Morus alba grown in trace elements contaminated soil. Lamontagne J, Sas E, Vincent G, Shang K, Pitre FE, Labrecque M. International Journal of Phytoremediation. Publié en ligne le 2 mars 2022

18. Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans. Possik E, Schmitt C, Al-Mass A, Bai Y, Côté L, Morin J, Erb H, Oppong A, Kahloan W, Parker JA, Madiraju SRM, Prentki M. Nature Communications. 2022, 13:177

17. Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota. Cuisinière T, Calvé A, Fragoso G, Oliero M, Hajjar R, Gonzalez E, Santos MM. BMC Microbiol. 2021. 21:259.

16. Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish. Heylen L, Pham D-H, De Meulemeester A-S, Samarut E, Skiba A, Copmans D, Kazwiny Y, Vanden Berghe P, de Witte PAM, Siekierska A. Frontiers in Molecular Neuroscience. 2021, 14:753936.

15. Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis. El-Far M, Durand M, Turcotte I, Larouche-Anctil E, Sylla M, Zaidan S, Chartrand-Lefebvre C, Bunet R, Ramani H, Sadouni M, Boldeanu I, Chamberland A, Lesage S, Baril J-G, Trottier B, Thomas R, Gonzalez E, Filali-Mouhim A, Goulet J-P, Martinson JA, Kassaye S, Karim R, Kizer JR, French AL, Gange SJ, Ancuta P, Routy J-P, Hanna DB, Kaplan RC, Chomont N, Landay AL, Tremblay CL and on behalf of the Canadian HIV and Aging Cohort Study (CHACS). Frontiers in Immunology. 2021 12:664371.

14. Adipose ABHD6 regulates tolerance to cold and thermogenic programs. Poursharifi P, Attané C, Mugabo Y, Al-Mass A, Ghosh A, Schmitt C, Zhao S, Guida J, Lussier R, Erb H, Chenier I, Peyot M-L, Joly E, Noll C, Carpentier AC, Madiraju SRM, Prentki M. JCI Insight. 2020 Dec 17; 5(24): e140294

13. Metabolite profiling identifies a signature of tumorigenicity in hepatocellular carcinoma. Cassim S, Raymond VA, Lacoste B, Lapierre P, Bilodeau M. Oncotarget. 2018 Jun 1;9(42):26868-26883.

12. Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment. Cassim S, Raymond VA, Dehbidi-Assadzadeh L, Lapierre P, Bilodeau M. Cell Cycle. 2018;17(7):903-916

11. Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome. Wilson AM, Shao Z, Grenier V, Mawambo G, Daudelin JF, Dejda A, Pilon F, Popovic N, Boulet S, Parinot C, Oubaha M, Labrecque N, de Guire V, Laplante M, Lettre G, Sennlaub F, Joyal JS, Meunier M, Sapieha P.  Science Immunoly. 2018 Mar 16;3(21):eaan4626.

10. Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model.  Lamontagne J, Al-Mass A, Nolan CJ, Corkey BE, Madiraju SRM, Joly E, Prentki M. Journal of Biological Chemistry. 2017 Nov 24;292(47):19458-19468.

9. Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells. Mugabo Y, Zhao S, Lamontagne J, Al-Mass A, Peyot ML, Corkey BE, Joly E, Madiraju SRM, Prentki M. Journal of Biological Chemistry. 2017 May 5;292(18):7407-7422.

8. From in vivo to in vitro: Major metabolic alterations take place in hepatocytes during and following isolation. Cassim S, Raymond VA, Lapierre P, Bilodeau M. PLoS One. 2017 Dec 28;12(12):e0190366.

7. Dietary Heme Induces Gut Dysbiosis, Aggravates Colitis, and Potentiates the Development of Adenomas in Mice.  Constante M, Fragoso G, Calvé A, Samba-Mondonga M, Santos MM. Frontiers in Microbiology. 2017 8:1809. eCollection

6. Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes. Mugabo Y, Zhao S, Seifried A, Gezzar S, Al-Mass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SR, Prentki M. PNAS U S A. 2016 Jan 26;113(4):E430-9.

5. α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. Fisette A, Tobin S, Décarie-Spain L, Bouyakdan K, Peyot ML, Madiraju SRM, Prentki M, Fulton S, Alquier T. Cell Reports. 2016 17(5):1217-1226

4. A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice. Attané C, Peyot ML, Lussier R, Poursharifi P, Zhao S, Zhang D, Morin J, Pineda M, Wang S, Dumortier O, Ruderman NB, Mitchell GA, Simons B, Madiraju SRM, Joly E, Prentki M. Diabetologia. 2016. 59(12):2654–2663.

3. A novel role for central ACBP/DBI as a regulator of long-chain fatty acid metabolism in astrocytes. Bouyakdan K, Taïb B, Budry L, Zhao S, Rodaros D, Neess D, Mandrup S, Faergeman NJ, Alquier T. Journal of Neurochemistry 2015 133:253-265

2. α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion.   Zhao S, Mugabo Y, Iglesias J, Xie L, Delghingaro-Augusto V, Lussier R, Peyot ML, Joly E, Taïb B, Davis MA, Brown JM, Abousalham A, Gaisano H, Madiraju SR, Prentki M. Cell Metabolism. 2014 Jun 3;19(6):993-1007.

1. A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic β-cells. Guay C, Joly E, Pepin E, Barbeau A, Hentsch L, Pineda M, Madiraju SR, Brunengraber H, Prentki M. PLoS One. 2013 Oct 10;8(10):e77097. 

Mise à jour : décembre 2024