Metabolomics

The CRCHUM’s Metabolomics Core Facility has contributed to the publication of nearly twenty scientific articles since 2013.

Metabolomics Core Facility Contributions

18. Very long-chain unsaturated sphingolipids mediate oleate-induced rat β-cell proliferation. Castell A-L, Vivoli A, Tippetts TS, Robillard Frayne I, Angeles ZE, Moullé VS, Campbell SA, Ruiz M, Ghislain J, Des Rosiers C, Holland WL, Summers SA, Poitout V. Diabetes. Published online March 14, 2022

17. Valuable alkaloids content is preserved in Camptotheca acuminata and Morus alba grown in trace elements contaminated soil. Lamontagne J, Sas E, Vincent G, Shang K, Pitre FE, Labrecque M. International Journal of Phytoremediation. Published online March 2, 2022

16. Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans. Possik E, Schmitt C, Al-Mass A, Bai Y, Côté L, Morin J, Erb H, Oppong A, Kahloan W, Parker JA, Madiraju SRM, Prentki M. Nature Communications. 2022, 13:177

15. Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish. Heylen L, Pham D-H, De Meulemeester A-S, Samarut E, Skiba A, Copmans D, Kazwiny Y, Vanden Berghe P, de Witte PAM, Siekierska A. Frontiers in Molecular Neuroscience. 2021, 14:753936.

14. Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis. El-Far M, Durand M, Turcotte I, Larouche-Anctil E, Sylla M, Zaidan S, Chartrand-Lefebvre C, Bunet R, Ramani H, Sadouni M, Boldeanu I, Chamberland A, Lesage S, Baril J-G, Trottier B, Thomas R, Gonzalez E, Filali-Mouhim A, Goulet J-P, Martinson JA, Kassaye S, Karim R, Kizer JR, French AL, Gange SJ, Ancuta P, Routy J-P, Hanna DB, Kaplan RC, Chomont N, Landay AL, Tremblay CL and on behalf of the Canadian HIV and Aging Cohort Study (CHACS). Frontiers in Immunology. 2021 12:664371.

13. Adipose ABHD6 regulates tolerance to cold and thermogenic programs. Poursharifi P, Attané C, Mugabo Y, Al-Mass A, Ghosh A, Schmitt C, Zhao S, Guida J, Lussier R, Erb H, Chenier I, Peyot M-L, Joly E, Noll C, Carpentier AC, Madiraju SRM, Prentki M. JCI Insight. 2020 Dec 17; 5(24): e140294

12. Metabolite profiling identifies a signature of tumorigenicity in hepatocellular carcinoma. Cassim S, Raymond VA, Lacoste B, Lapierre P, Bilodeau M. Oncotarget. 2018 Jun 1;9(42):26868-26883.

11. Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment. Cassim S, Raymond VA, Dehbidi-Assadzadeh L, Lapierre P, Bilodeau M. Cell Cycle. 2018;17(7):903-916

10. Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome. Wilson AM, Shao Z, Grenier V, Mawambo G, Daudelin JF, Dejda A, Pilon F, Popovic N, Boulet S, Parinot C, Oubaha M, Labrecque N, de Guire V, Laplante M, Lettre G, Sennlaub F, Joyal JS, Meunier M, Sapieha P.  Science Immunoly. 2018 Mar 16;3(21):eaan4626.

9. Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model.  Lamontagne J, Al-Mass A, Nolan CJ, Corkey BE, Madiraju SRM, Joly E, Prentki M. Journal of Biological Chemistry. 2017 Nov 24;292(47):19458-19468.

8. Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells. Mugabo Y, Zhao S, Lamontagne J, Al-Mass A, Peyot ML, Corkey BE, Joly E, Madiraju SRM, Prentki M. Journal of Biological Chemistry. 2017 May 5;292(18):7407-7422.

7. From in vivo to in vitro: Major metabolic alterations take place in hepatocytes during and following isolation. Cassim S, Raymond VA, Lapierre P, Bilodeau M. PLoS One. 2017 Dec 28;12(12):e0190366.

6. Dietary Heme Induces Gut Dysbiosis, Aggravates Colitis, and Potentiates the Development of Adenomas in Mice.  Constante M, Fragoso G, Calvé A, Samba-Mondonga M, Santos MM. Frontiers in Microbiology. 2017 8:1809. eCollection

5. Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes. Mugabo Y, Zhao S, Seifried A, Gezzar S, Al-Mass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SR, Prentki M. PNAS U S A. 2016 Jan 26;113(4):E430-9.

4. α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. Fisette A, Tobin S, Décarie-Spain L, Bouyakdan K, Peyot ML, Madiraju SRM, Prentki M, Fulton S, Alquier T. Cell Reports. 2016 17(5):1217-1226

3. A novel role for central ACBP/DBI as a regulator of long-chain fatty acid metabolism in astrocytes. Bouyakdan K, Taïb B, Budry L, Zhao S, Rodaros D, Neess D, Mandrup S, Faergeman NJ, Alquier T. Journal of Neurochemistry 2015 133:253-265

2. α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion.   Zhao S, Mugabo Y, Iglesias J, Xie L, Delghingaro-Augusto V, Lussier R, Peyot ML, Joly E, Taïb B, Davis MA, Brown JM, Abousalham A, Gaisano H, Madiraju SR, Prentki M. Cell Metabolism. 2014 Jun 3;19(6):993-1007.

1. A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic β-cells. Guay C, Joly E, Pepin E, Barbeau A, Hentsch L, Pineda M, Madiraju SR, Brunengraber H, Prentki M. PLoS One. 2013 Oct 10;8(10):e77097.