Shilei DING

PhD

Research associate,  Immunopathology
Shilei DING

Contact

Phone: 514-890-8000, ext. 24308

Email: shilei.ding@mail.mcgill.ca

Publications

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Job

Specialist Experimental imaging core facility, CRCHUM

Research Interests

  1. Research on HIV envelope glycoprotein (Env): Small-molecule CD4 mimetics (CD4mc) such as BNM-III-170 and MCG-IV-210 sensitize HIV-1-infected cells to antibody-dependent cellular cytotoxicity (ADCC) mediated by non-neutralizing-Abs (nnAbs) present in plasma from people living with HIV (PLWH). We are optimizing MCG-IV-210 analogs that can gain breadth and ADCC activity;
  2. Develop compounds for the treatment of SARS-CoV-2 infection:  Small molecule VE607 is a broadly inhibitor for major SARS-CoV-2 variants of concern (VOCs). We found that it binds to the receptor binding domain (RBD)-ACE2 interface and stabilizes RBD in its “up” conformation. VE607 derived analogs will be tested to improve the in vivo efficacy;
  3. Build up procedures for utilizing replicating authentic SARS-CoV-2 viruses: test neutralization or ADCC with Abs or compounds using replicating authentic SARS-CoV-2 variant viruses infected cells.     

Expertises

Researcher in charge

Immunopathology

The Immunopathology Research Theme comprises a group of researchers spanning the basic and clinical research continuum and focusing on the immune/inflammatory processes involved in the disturbance and restoration of homeostasis. These activities are rooted in shared visions regarding explorat…

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Manipulations de laboratoire
CHUM

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